Effect of Fatty Acids on Interleukin 2 Signaling Pathway in Human Lymphocytes
نویسندگان
چکیده
منابع مشابه
Regulation of interleukin-2 signaling by fatty acids in human lymphocytes.
Docosahexaenoic (DHA; C22:6 n-3), eicosapentaenoic (EPA; C20:5 n-3), palmitic (PA; C16:0), and stearic (SA; C18:0) acids decrease lymphocyte proliferation in concentrations of >50 muM, as observed in our previous study. However, oleic acid (OA; C18:1 n-9) and linoleic acid (LA; C18:2 n-6) increase lymphocyte proliferation at 25 muM. In this study, the effect of these FAs on the interleukin-2 (I...
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The aim of the present study was to investigate the mechanisms involved in the modulation of human lymphocyte proliferation by different fatty acids. We evaluated the effects of palmitic (PA), stearic (SA), oleic (OA), linoleic (LA), docosahexaenoic (DHA), and eicosapentaenoic (EPA) acids on IL-2 signaling pathways in addition to the involvement of the de novo ceramide synthesis and PI3K pathwa...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2007
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.21.6.a1212